Frequently Asked Questions, continued 4. How long does it take for the NEUPRO Patch to start working? Your doctor should start you on a low dose of NEUPRO. Your doctor may change the dose weekly until you are taking the right amount of medicine to control your symptoms. It may take several weeks before you reach the dose that controls your symptoms best. 5. What should I avoid while taking NEUPRO? Do not drive, operate machinery, or do other dangerous activities until you know how NEUPRO affects you. A void exposing the NEUPRO Patch you are wearing to heating pads, electric blankets, heat lamps, saunas, hot tubs, heated waterbeds, and direct sunlight. Too much medicine could be absorbed into your body. D o not use NEUPRO during certain medical procedures called magnetic resonance imaging (MRI) or cardioversion. Using NEUPRO during these procedures could cause a burn to the site where you applied your NEUPRO Patch. 6. Do I have to apply my NEUPRO Patch around mealtime? No. Apply your patch when it’s convenient for you, and apply it at the same time each day. Because NEUPRO is delivered through the skin, food should not affect the medication. 7. Why do I need to hold the NEUPRO Patch on for at least 30 seconds? Press your NEUPRO Patch firmly with the palm of your hand for 30 seconds to make sure there is good contact with your skin, especially around the edges. The warmth of your hand helps the adhesive on the patch stick to your skin. Make sure that your NEUPRO Patch is flat against your skin. There should be no bumps or folds in your NEUPRO Patch. 8. How can I prevent skin irritation or other skin-related side effects? You need to change the location of the NEUPRO Patch on a daily basis and should not use the same location for 14 days. Changing the location will reduce the chance of skin irritation. You may see mild redness, like when you remove an adhesive bandage, which is normal. Of course, always check with your doctor if you have any concerns.