What Is RLS? * Restless Legs Syndrome (RLS) is a neurological disorder that results in a powerful urge to move your legs (and, sometimes, other parts of your body). RLS affects up to 23 million American adults; it is estimated that a third have moderate-to-severe RLS. Symptoms tend to get worse in the evening and at night, and keep people from resting and relaxing, and may even affect sleep. *Restless Legs Syndrome is also known as Willis-Ekbom disease. Important Safety Information NEUPRO may make you fall asleep suddenly or without warning while doing normal activities, such as driving, which may result in accidents. Tell your doctor right away if this happens. Drinking alcohol or taking other medicines that cause drowsiness may increase your chances of becoming sleepy while using NEUPRO. Do not drive, use hazardous machinery, or do other dangerous activities until you know how NEUPRO affects you. These are legs. They keep me moving. Even when I am trying to sleep.