What are the ingredients in NEUPRO? Active ingredient: rotigotine Inactive ingredients: ascorbyl palmitate, povidone, silicone adhesive, sodium metabisulfite, and dl-alpha- tocopherol. INSTRUCTIONS FOR USE NEUPRO® [NU pro] (rotigotine transdermal system) When to apply NEUPRO: Each NEUPRO patch is sealed in a pouch that protects it until you are ready to apply it. See Figure A. Figure A • NEUPRO should be applied right away after removing it from the protective pouch. Do not damage or cut your NEUPRO patch into smaller pieces. • Choose the time of day or night that works best for you to apply your NEUPRO patch. Apply your NEUPRO patch at the same time each day. • Wear your NEUPRO patch for 24 hours. • After 24 hours, remove your NEUPRO patch and apply a new one right away to a different area of your skin. Where to apply NEUPRO: • Choose an area of clean, dry, and healthy skin on the stomach, thigh, hip, side of the body between the ribs and the pelvis (flank), shoulder, or upper arm. See Figure B.

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