• unusual urges. Some patients using NEUPRO get urges to behave in a way unusual for them. Examples of this are an unusual urge to gamble, strong urges to spend money, binge eating, or increased sexual urges and behaviors. If you notice or your family notices that you are developing any unusual behaviors, talk to your doctor. • changes in heart rate. NEUPRO can increase your heart rate. • skin site reactions. Skin reactions may occur at the site where you apply NEUPRO. Tell your doctor if you get a rash, redness, swelling, or itching that will not go away at the skin site where you have applied NEUPRO. • changes in Restless Legs Syndrome symptoms. NEUPRO may cause Restless Legs Syndrome symptoms to come back (rebound), or become worse or start earlier in the day. The most common side effects of NEUPRO for Restless Legs Syndrome (RLS) are application site reactions, nausea, difficulty falling asleep and staying asleep, sleepiness, and headache. Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of NEUPRO. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. How should I store NEUPRO? • Store NEUPRO at 68°F to 77°F (20°C to 25°C). • Store NEUPRO in its original sealed pouch until use. Do not store NEUPRO outside of the pouch. Keep NEUPRO and all medicines out of reach of children and away from pets. General information about the safe and effective use of NEUPRO. Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use NEUPRO for a condition for which it was not prescribed. Do not give NEUPRO to other people even if they have the same symptoms you have. It may harm them. This Patient Information leaflet summarizes the most important information about NEUPRO. If you would like more information, talk with your doctor. You can ask your pharmacist or doctor for information about NEUPRO that was written for health professionals. For more information, go to www.neupro.com or call 1-844-599-2273. What are the ingredients in NEUPRO? Active ingredient: rotigotine Inactive ingredients: ascorbyl palmitate, povidone, silicone adhesive, sodium metabisulfite, and dl-alpha- tocopherol. INSTRUCTIONS FOR USE ® NEUPRO [NU pro] (rotigotine transdermal system) When to apply NEUPRO: Each NEUPRO patch is sealed in a pouch that protects it until you are ready to apply it. See Figure A.